The development of digital technology has brought startup actors to become creative entrepreneurs, thus giving birth to a new generation called technopreneurship. Previous research mostly focused on the technical and hard aspects of technology and the human inventing the technology. However, in today’s era, setting a digital strategy, innovations that are dominated by technological adaptations are considered necessary but not sufficient if the role of human resources through human creativity is not addressed as important element of the equation. This study aims to find the influence of digital strategy and human creativity in shaping the transformation of technopreneurship in startups. There needs to be an intuitive process as part of controlling soft information that digital products cannot handle. Sharpness of intuition in doing business and in extracting the value of technological transformation will ultimately lead startups to competitive advantage which is the first step towards success in carrying out technopreneurship transformation. This research was conducted using quantitative research methods through a structured survey instrument. The sample was taken from 105 respondents, namely startup founders spread across several regions in Indonesia. The reliability and validity of the instrument were tested by Cronbach's Alpha, Average Variance Extracted (Pvc) and Composite Reliability (Pc). Data analysis using Smartpls 3.0. The results showed that the relationship between exogenous latent variables, namely digital strategy and human creativity, was proven to be significant and influenced the formation of technopreneurship transformation in startups. From the Path Coefficient value obtained, it means that the greater the digital strategy and human creativity owned by the startup, the higher the technopreneurship transformation.